Thyroid Stimulating Hormone Receptor (TSHR)
TSHR ThyroidStimulating Hormone Receptor (TSHR)
The TSH testis a member of the G protein-coupled receptor superfamily of integral membrane proteins.
The thyrotropin receptor (or TSH receptor) locates primarily in the body of the thyroid gland. It recognizes and binds to stimulating thyroid hormone (also known as "thyrotropin") secreted from the pituitary gland.
TSH stimulates the production of thyroxine (T4) and triiodothyronine (T3).
TSHR is closely related to the pathogenesis of various autoimmune thyroid diseases and is an essential indicator for the clinical diagnosis of these diseases.
SEKBIO is now offering Mouse anti-human TSHR mAb, Humanized anti-human TSHR mAb, Recombinant human sTSHR (Soluble), and human TSHR extractive of cell membranes (Full length) for diagnosis usage.
TSHR
Thyroid-stimulating hormone receptor (TSHR) and its homologous luteinizing hormone/chorionic gonadotropin receptor and follicle-stimulating hormonesreceptor belong to a class of glycoprotein receptors. They are also visual A member of the large family of G protein-coupled receptors (GPcRs) of rhodopsin (approximately 45% identity at the amino acid level). TSHR is mainly expressed in thyroid follicular cells and activates the protein kinase A (PKA) and phospholipase C (Phospholipases C, PLc) signal transduction systems after combining with thyroid-stimulating hormone (TSH) under physiological conditions. , regulate the growth and differentiation of the thyroid, and promote the synthesis and release of thyroid hormones.
Anti TSH Antibody
The expression of TSHR can also be found in other cells or tissues, including adipocytes, fibroblasts, osteoblasts and osteoclasts, bone marrow cells and cardiomyocytes, etc., and is expressed in embryonic stem cells at an early stage. In autoimmune thyroid diseases, especially toxic diffuse goiter (Graves' disease, GD), TSHR can act as an autoantigen and bind to thyroid-stimulating antibody (TSAb) to produce TSH-like stimulation. The reaction will eventually lead to the loss of thyroid autoimmune tolerance, production and release of excessive thyroid hormones, and clinical manifestations of hyperthyroidism such as palpitations, sweating, and hyperthyroidism. Therefore, studying the structure of thyroid-stimulating hormone receptors and elucidating the interaction between autoantibodies and thyroid-stimulating hormone receptor (TSHR) molecules is vital for understanding Graves disease's pathogenesis, a common organ-specific autoimmune disease, and guiding clinical practice. Diagnosis and treatment have far-reaching significance.
If you want to know more details of tsh blocking antibodiesand tsh stimulating antibodies, please visit our website.
Send product request
Other supplier products
 |
Testosterone (Testo) | Testosteroneis the primary male sex hormone and an anabolic steroid. In male humans, testosterone plays a vital role in developing male reproductiv... |
 |
Recombinant Human Neuron-specific Enolase (Prokaryotic NSE Protein Full Length) | Name: Recombinant human neuron-specific enolase (Prokaryotic NSE protein full length) Catalog No.: ZLP113-1 Description: Recombinant protein Epi... |
 |
HE4 Tumor Marker | Human Epididymis Protein 4 (HE4 tumor marker) Is a Secreted Glycoprotein that Serous and Endometrioid Ovarian Carcinomas overexpress. CA 125 is th... |
 |
Thyroglobulin (Tg) | Thyroid thyroglobulinis a 660 kDa, a dimeric glycoprotein produced by the follicular cells of the thyroid and released into the residual cavity of ... |
 |
Triiodothyronine (T3) | Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and developme... |
Same products
 |
Creatine Kinase-MB (CKMB) | Seller: Shenzhen SEKBIO Co., Ltd | Creatine kinase isoenzymes are an enzyme component, among which MB type is mainly present in myoc... |
 |
C-Reaction Protein (CRP) | Seller: Shenzhen SEKBIO Co., Ltd | C-reactive protein (CRP) refers to several proteins (acute proteins) that rise sharply in blood p... |
 |
Cardiac Troponin I (cTnI) | Seller: Shenzhen SEKBIO Co., Ltd | Cardiac troponin I, often denoted as cTnI, is presented in cardiac muscle tissue by a single isof... |
 |
CA50 Tumor Marker | Seller: Shenzhen SEKBIO Co., Ltd | CA50 is a kind of sialic acid ester and sialic acid glycoprotein, which generally does not exist ... |
 |
CA242 Tumor Marker | Seller: Shenzhen SEKBIO Co., Ltd | CA242, or Cancer Antigen 242, is a notable glycoprotein biomarker within the realm of oncology an... |
